Joshua Chiou

Senior Advisor, Genomics · Lilly · Translational Proteomics & Statistical Genetics

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I am a Senior Advisor in Genomics at Lilly, and I translate large-scale proteomics into mechanistic insights to inform clinical strategy for obesity drug programs. Previously, I was a Senior Principal Computational Geneticist at Pfizer, where I led cardiovascular target discovery using human genetics and contributed to the UK Biobank Pharma Proteomics Project (UKB-PPP).

I completed my PhD in Biomedical Sciences at UC San Diego, where I used statistical genetics and single-cell epigenomics to study type 1 and type 2 diabetes risk mechanisms.

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38 Publications
7529 Citations
27 h-index
9 papers in Nature Nature Genetics Cell
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news

Mar 26, 2026 Fixed a memory leak in the ha-esunpower Home Assistant integration that crashed on PVS gateways configured with an IP address.
Feb 12, 2026 Packaged r-mmrm for conda-forge — making the Mixed Models for Repeated Measures R package available as a conda dependency for clinical trial analysis pipelines.
Oct 20, 2025 Joined Lilly as Senior Advisor, Genomics, working on translational proteomics for obesity clinical trials.
Oct 02, 2023 Promoted to Senior Principal Computational Geneticist in the Internal Medicine Research Unit at Pfizer.
Sep 18, 2023 Our paper on plasma proteomic associations with genetics and health in the UK Biobank Pharma Proteomics Project is published in Nature.
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selected publications

38 publications · Google Scholar · ORCID
*Equal contribution · Chiou J = self
  1. Plasma proteomic associations with genetics and health in the UK Biobank
    Sun BB, Chiou J, Traylor M, and 62 more authors
    Nature, 2023
    DOI Scholar View project
  2. Interpreting type 1 diabetes risk with genetics and single-cell epigenomics
    Chiou J, Geusz RJ, Okino M, and 13 more authors
    Nature, 2021
    DOI Scholar View project
  3. Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes
    Wang G*, Chiou J*, Zeng C, and 18 more authors
    *Equal contribution
    Nature Genetics, 2023
    DOI Scholar
  4. Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk
    Chiou J*, Zeng C*, Zhang C, and 17 more authors
    *Equal contribution
    Nature Genetics, 2021
    DOI Scholar View project
  5. Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk
    Greenwald WW*, Chiou J*, Yan J, and 19 more authors
    *Equal contribution
    Nature Communications, 2019
    DOI Scholar